Curcumin & Cannabis Crossover Effects In The Brain (Endocannabinoid System)



Curcumin & Cannabis Crossover Effects In The Brain (Endocannabinoid System)

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Curcumin Phytosome (Soy Free) contains all 3 curcuminoids [i.e. the active ingredients naturally present in turmeric] in the same proportions expected in nature, and it is the formulation with the highest plasmatic levels of DMC [the most potent curcuminoid]. Curcumin Phytosome is based on a natural and foodgrade delivery system [Phytosome] of a standardized turmeric extract containing the full bouquet of curcuminoids and stands as the most pre-clinically and clinically documented curcumin bioavailable formulation and is considered to exhibit powerful anti-inflammatory properties.

In the present study, we have demonstrated that chronic exposure to curcumin or the
conventional antidepressant amitriptyline evokes a sustained elevation of NGF in dose-dependent and brain region-specific fashion (Fig. 2a–c). Enhancement of brain
NGF levels following chronic, but not acute, treatment suggests that the neurotrophic effect of an antidepressant is a slowly developing process. According to Yanpallewar et al. [49], the increased expression of a trophic factor is usually considered as a slow-onset adaptive change.
Sustained elevation of NGF contents in the brain structures involved in the regulation of emotions (Fig. 2a–c) may be considered as an underlying mechanism through which
curcumin, similar to the positive control amitriptyline, exerts its beneficial effects against neuropsychiatric disorders or further brain damage caused by chronic stress.
According to the stimulatory effect of NGF on cell proliferation [50], elevation of the frontal cortex NGF following chronic treatment with curcumin or amitriptyline (Fig. 2) might be of therapeutic importance against stressinduced reduction in cell proliferation and pathogenic deficits in the frontal cortex which is likely to be implicated in depression and is sensitive to the effect of antidepressant treatment [51]. As shown in Fig. 2, chronic administration of curcumin or amitriptyline resulted to a significant increase in hippocampal NGF content. Since NGF plays a critical role in the hippocampal plasticity and neurogenesis [52] and is implicated in the cognitive function via the induction of acetylcholine release in the hippocampus [53], therefore, it is reasonable to speculate that curcumin and amitriptyline induce hippocampal neurogenesis.

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