Bryan Johnson Claims to Reverse Biological Age to That of a 10-Year-Old with Oxygen Therapy
By Young By Choice™ Editorial Team | Date: June 6, 2025
A major headline in the world of longevity and biohacking today centers on tech entrepreneur and biohacker Bryan Johnson, who has made a striking claim: after 90 days of intense hyperbaric oxygen therapy (HBOT), he says his biological markers now resemble those of a 10-year-old child 2 6.
What Happened?
Bryan Johnson, already famous for his multi-million-dollar anti-aging regimen known as “Blueprint,” recently completed a 90-day protocol involving daily sessions in a hyperbaric oxygen chamber. This therapy involves breathing 95–100% pure oxygen at elevated atmospheric pressure, which allows oxygen to dissolve more deeply into the bloodstream and reach tissues that may be oxygen-starved 2 6.
Reported Results
Johnson claims that, following this regimen combined with his strict lifestyle (plant-based diet, rigorous exercise, sleep optimization, and regular medical testing), he has achieved:
Dramatic improvements in skin health
Reduction in biological age markers
Enhanced lung and cardiovascular function
Better cognitive performance and sleep quality
He asserts that his overall biological profile now matches that of a pre-teen, based on a battery of biomarker tests 2 6.
The Science Behind HBOT
Hyperbaric oxygen therapy is FDA-approved for several medical uses, such as treating non-healing wounds and decompression sickness. In recent years, it has gained attention for its potential anti-aging benefits, including:
Increased production of stem cells for tissue regeneration
Reduced inflammation
Improved mitochondrial function
Potential extension of telomeres, the DNA caps that shorten with age
A notable 2020 Israeli study found that HBOT could lengthen telomeres and reduce the number of senescent (aging) cells, supporting some of Johnson’s claims 2.
Expert Caution
While Johnson’s results are headline-grabbing, medical experts urge caution. HBOT is not without risks—prolonged exposure can cause oxygen toxicity, barotrauma, and vision changes. The therapy is also expensive and requires close medical supervision. Experts emphasize that more peer-reviewed research is needed before HBOT can be widely recommended as an anti-aging intervention 2 6.
“Bryan Johnson’s experiment opens up exciting, if controversial, possibilities in the field of anti-aging and longevity science. It challenges traditional views of aging as a linear, irreversible process and suggests that, with the right tools, we might not only delay aging but potentially rewind certain biological clocks.”2
Takeaway
Bryan Johnson’s bold experiment with hyperbaric oxygen therapy is making waves in the longevity and biohacking community, fueling debate about the future of anti-aging science. While his personal results are not yet a prescription for the masses, they spotlight the rapid evolution of longevity research and the tantalizing possibility of truly reversing aspects of biological aging 2 6.
For more on the science and skepticism behind biohacking and anti-aging breakthroughs, stay tuned to our Latest Breaking News section.
