Can You Live Past 120? Exploring Molecular Science and Longevity Breakthroughs

Molecular Science of Longevity: Can You ACTUALLY Live Past 120 Years?

What if the secret to living past 120 years lies in a molecule already present in your body? In a fascinating discussion on the Human Upgrade Podcast with Dave Asprey, Dr. Andrew Salzman, a Harvard-trained physician and longevity researcher, dives deep into the science of NAD (Nicotinamide Adenine Dinucleotide) and its pivotal role in energy production, DNA repair, and overall health. This article explores the groundbreaking insights shared in the episode, shedding light on how NAD could revolutionize our approach to aging and longevity.

What is NAD and Why Does It Matter?

NAD is a small but mighty molecule that serves as the “centerpiece of biology.” According to Dr. Salzman, NAD performs three critical functions in the body:

1. Energy Production: NAD is essential for the creation of ATP, the energy currency of our cells.
2. Antioxidant Defense: It helps protect the body from oxidative stress by producing NADPH, which drives the production of glutathione and other antioxidants.
3. DNA Repair: NAD powers enzymes like PARP (Poly ADP-Ribose Polymerase), which repair DNA damage caused by environmental factors and aging.

Without sufficient NAD, our cells lose their ability to function optimally, leading to energy depletion, increased oxidative damage, and a higher risk of diseases like cancer, cardiovascular issues, and neurodegeneration.

The Aging Process: A Unified Theory

Dr. Salzman challenges the traditional view of diseases as isolated events, such as “bad luck” diabetes or cancer. Instead, he argues that aging is the root cause of most chronic conditions. As we age, our body’s ability to repair itself diminishes, leading to systemic dysfunction across organs. For example:

• Arthritis is not just a joint issue; it’s a symptom of aging.
• Cardiovascular disease stems from oxidative damage and inflammation, both of which are exacerbated by declining NAD levels.

By addressing the aging process itself—rather than its symptoms—we can potentially prevent or delay the onset of multiple diseases.

Can Humans Live Beyond 120 Years?

The current human lifespan peaks at around 120 years, but Dr. Salzman believes this is not an unbreakable barrier. He explains that longevity is influenced by two factors:

1. Accumulation of Damage: Over time, DNA damage, oxidative stress, and inflammation take their toll on the body.
2. Genetic and Environmental Factors: Some species, like the Greenland shark, live for centuries due to enhanced DNA repair mechanisms.

By leveraging advancements in AI, biotechnology, and molecular science, Dr. Salzman predicts that humans could extend their lifespan to 130 or even 140 years within the next decade.

The Role of NAD in Longevity

Maintaining optimal NAD levels is crucial for longevity. However, as we age, NAD levels naturally decline due to increased consumption by enzymes like CD38, which becomes overactive in response to inflammation and immune activation.

To counteract this, Dr. Salzman recommends a two-pronged approach:

1. Boost NAD Levels: Through supplements like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside), which are precursors to NAD.
2. Inhibit NAD Depletion: By targeting CD38 with natural compounds like resveratrol (from red grapes) and hydroxytyrosol (from olive oil), which are included in products like Wonderfeel.

Practical Applications of NAD

Dr. Salzman highlights several areas where NAD supplementation can have profound effects:

1. Cardiovascular Health: NAD protects blood vessels from oxidative damage, reducing the risk of hypertension and atherosclerosis.
2. Brain Function: NAD supports mitochondrial energy production in the brain, improving memory, focus, and reducing brain fog.
3. Gut Health: NAD helps maintain the integrity of the gut lining, preventing “leaky gut” and systemic inflammation.
4. Sexual Health: NAD is essential for nitric oxide production, which improves blood flow and sexual function.
5. Recovery from Chronic Conditions: NAD supplementation has shown promise in addressing long COVID, chronic fatigue syndrome, and other inflammatory conditions.

The Future of Longevity Science

Dr. Salzman emphasizes the importance of a holistic approach to longevity, combining NAD supplementation with lifestyle interventions like exercise, a nutrient-dense diet, and stress management. He also advocates for ongoing research to refine our understanding of NAD and its role in aging.

Key Takeaways

• NAD is a cornerstone of cellular health, influencing energy production, DNA repair, and antioxidant defense.
• Aging is not an isolated process but a systemic issue that can be addressed by targeting its root causes.
• By boosting NAD levels and inhibiting its depletion, we can potentially extend both lifespan and healthspan.
• Emerging research and innovations in biotechnology could soon make living past 120 years a reality.

“Your choices today are the foundation of your vitality tomorrow.” – Young By Choice

Resources

• Original Podcast Episode: Molecular Science of Longevity: Can You ACTUALLY Live Past 120 Years? | Andrew Salzman
• Reference: Asprey, D. (Host). (2025). The Human Upgrade Podcast. Featuring Dr. Andrew Salzman.