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Turning Back the Clock: Can We Reverse Aging?

Young By ChoiceSeptember 16, 20231 Mins read151 Views

Turning Back the Clock: Can We Reverse Aging?

Turning back age

The pursuit of longer, healthier lives has led to exciting new anti-aging research. At the forefront is scientist David Sinclair, who believes we can harness cells’ natural ability to reverse the aging process.

Cellular Reprogramming:

Sinclair’s work focuses on cellular reprogramming – essentially turning back the clock in our cells. As we age, our cells enter a senescent state, accumulating damage and stopping division. Sinclair discovered that by activating certain genes, senescent cells can be reverted to a youthful, stem cell-like state.

This “backward aging” protocol has achieved remarkable results in animal studies. Mice treated with cellular reprogramming therapy showed improved organ function, hair regrowth, and fitness. Human trials are now planned to test the safety and efficacy of this approach.

Sinclair takes cellular reprogramming a step further with his “Yamanaka factors.” Named for Nobel prize winner Shinya Yamanaka, these four genes can convert mature cells into induced pluripotent stem cells. Delivering Yamanaka factors to targeted tissues may someday allow our bodies to regenerate and repair age-related damage.

Sinclair practices what he preaches, adhering to a longevity regimen he outlines in his book Lifespan (https://lifespanbook.com). This includes time-restricted eating, fasting mimicking diets, exercise targeted to muscle and bone health, and supplements like NAD+ boosters. He recommends 100-500 mg per day of nicotinamide riboside starting by age 40, and 50-100 mg per day of resveratrol starting by age 50. For cellular senolytics, he advises quantity and frequency depending on age.

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